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Article

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

Science signaling - 27 Jan 2009

Marshall Christopher B, Ho Jason, Buerger Claudia, Plevin Michael J, Li Guang-Yao, Li Zhihong, Ikura Mitsuhiko, Stambolic Vuk

Abstract excerpt

Tuberous sclerosis complex 2 (TSC2), whose gene is frequently mutated in tuberous sclerosis, increases the guanosine triphosphatase (GTPase) activity of the small heterotrimeric GTP-binding protein (G protein) Rheb, thus resulting in the decreased activity of the mammalian target of rapamycin (mTOR), the master regulator of cell growth. Here, we describe the development of a nuclear magnetic resonance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19176517
DOI: 10.1126/scisignal.2000029

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.PMID 19176517Read ↗

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.Semantic proximity Read ↗

Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).Semantic proximity Read ↗

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Semantic proximity Read ↗

The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction.Semantic proximity Read ↗

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis PathogenesisSemantic proximity Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.Semantic proximity Read ↗

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.Semantic proximity Read ↗

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.Semantic proximity Read ↗

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.Semantic proximity Read ↗

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.Semantic proximity Read ↗

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