Article
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Science (New York, N.Y.) - 31 May 2013
Bar-Peled Liron, Chantranupong Lynne, Cherniack Andrew D, Chen Walter W, Ottina Kathleen A, Grabiner Brian C, Spear Eric D, Carter Scott L, Meyerson Matthew, Sabatini David M
Abstract excerpt
The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues, including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to promote mTORC1 translocation to the lysosomal surface, its site of activation. Although progress has been made in identifying positive regulators of the Rags, it is unknown if negative factors also exist. Here, we identify GATOR as a complex...
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