Article

Structural insights into TSC complex assembly and GAP activity on Rheb

2020-07-07

Abstract excerpt

<title>Abstract</title> <p>Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1. Mutations in TSC genes cause tuberous sclerosis. In this study, the near-atomic resolution structure of human TSC complex reveals an arch...

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Literature Corpus work: 057d5568-256e-5ad4-b754-8007c97f1b94
DOI: 10.21203/rs.3.rs-36453/v1

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