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Article

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.

Oncogene - 21 Jan 2010

Hanker A B, Mitin N, Wilder R S, Henske E P, Tamanoi F, Cox A D, Der C J

Abstract excerpt

The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C=cysteine, A=aliphatic, X=terminal amino acid) motif, a substrate for posttranslational modification by a farnesyl isoprenoid. After farnesylation, Rheb undergoes two additional CAAX-signaled...

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Identifiers

PMID: 19838215
DOI: 10.1038/onc.2009.336
PMCID: PMC2809798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.PMID 19838215Read ↗

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