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Article

Rheb binds and regulates the mTOR kinase.

Current biology : CB - 26 Apr 2005

Long Xiaomeng, Lin Yenshou, Ortiz-Vega Sara, Yonezawa Kazuyoshi, Avruch Joseph

Abstract excerpt

BACKGROUND: The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation. Genetic evidence establishes that TOR complex activity in vivo requires the small GTPase Rheb, and overexpression of Rheb can rescue TOR from inactivation in vivo by amino-acid withdrawal. The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions...

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Topics

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Share to Guanosine Triphosphate
Share to Immunoblotting
Share to Monomeric GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuropeptides

Share to Protein Kinases

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to TOR Serine-Threonine Kinases

Share to Tuberous Sclerosis Complex 2 Protein

Source

Identifiers

PMID: 15854902
DOI: 10.1016/j.cub.2005.02.053

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rheb binds and regulates the mTOR kinase.PMID 15854902Read ↗

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.Semantic proximity Read ↗

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.Semantic proximity Read ↗

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.Semantic proximity Read ↗

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Semantic proximity Read ↗

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.Semantic proximity Read ↗

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.Semantic proximity Read ↗

Structural insights into TSC complex assembly and GAP activity on RhebSemantic proximity Read ↗

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.Semantic proximity Read ↗

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.Semantic proximity Read ↗

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).Semantic proximity Read ↗

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.Semantic proximity Read ↗

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.Semantic proximity Read ↗

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