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Article

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Genes & development - 1 Aug 2003

Inoki Ken, Li Yong, Xu Tian, Guan Kun-Liang

Abstract excerpt

Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1. These functions of TSC1/TSC2 are likely mediated by mTOR. Here we report that TSC2 is a GTPase-activating protein (GAP) toward Rheb, a Ras family GTPase. Rheb stimulates phosphorylation of S6K and 4EBP1. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12869586
DOI: 10.1101/gad.1110003
PMCID: PMC196227

Genes

TSC2
TSC1

Variants

Provenance

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