Article
Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis.
Neuron - 2 Sept 2004
Wang Jian, Ma Xiaojun, Yang Jacob S, Zheng Xiaoyan, Zugates Christopher T, Lee Ching-Hsien J, Lee Tzumin
Abstract excerpt
Besides 19,008 possible ectodomains, Drosophila Dscam contains two alternative transmembrane/juxtamembrane segments, respectively, derived from exon 17.1 and exon 17.2. We wondered whether specific Dscam isoforms mediate formation and segregation of axonal branches in the Drosophila mushroom bodies (MBs). Removal of various subsets of the 12 exon 4s does not affect MB neuronal morphogenesis, while expression of a...
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