Article
Stochastic yet biased expression of multiple Dscam splice variants by individual cells.
Nature genetics - 1 Mar 2004
Neves Guilherme, Zucker Jacob, Daly Mark, Chess Andrew
Abstract excerpt
The Drosophila melanogaster gene Dscam is essential for axon guidance and has 38,016 possible alternative splice forms. This diversity can potentially be used to distinguish cells. We analyzed the Dscam mRNA isoforms expressed by different cell types and individual cells. The choice of splice variants expressed is regulated both spatially and temporally. Different subtypes of photoreceptors express broad yet...
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