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Article

Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jun 2007

Shi Lei, Yu Hung-Hsiang, Yang Jacob S, Lee Tzumin

Abstract excerpt

Drosophila Dscam isoforms are derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of ectodomain variants. Using a microRNA-based RNA interference technology, we selectively knocked down different subsets of Dscams containing either the exon 17.1- or exon 17.2-encoding TM. Eliminating Dscam[TM1] reduced Dscam expression but minimally affected postembryonic axonal...

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Identifiers

PMID: 17581959
DOI: 10.1523/JNEUROSCI.1517-07.2007
PMCID: PMC6672701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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