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Article

Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics.

Current pharmaceutical design - 1 Jan 2008

Listì F, Caruso M, Incalcaterra E, Hoffmann E, Caimi G, Balistreri C R, Vasto S, Scafidi V, Caruso C, Candore G

Abstract excerpt

Inflammation and genetics play an important role in the pathogenesis of coronary heart disease (CHD). However, despite the increasing appreciation of the role of genetics in CHD and myocardial infarction (MI) pathogenesis, pharmacogenomic approaches to uncover drug target have not been extensively explored. Cyclo-oxygenases (COXs) and 5-lipoxygenase (5-LO) are the key enzymes in the conversion of arachidonic acid...

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Identifiers

PMID: 18991687
DOI: 10.2174/138161208786264115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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