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Article

Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

Circulation - 4 Jul 2006

Podgoreanu M V, White W D, Morris R W, Mathew J P, Stafford-Smith M, Welsby I J, Grocott H P, Milano C A, Newman M F, Schwinn D A

Abstract excerpt

BACKGROUND: The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk...

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Identifiers

PMID: 16820586
DOI: 10.1161/CIRCULATIONAHA.105.001032
PMCID: PMC1945056

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