Article
Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.
International journal of immunogenetics - 1 Dec 2005
Chiappelli M, Tampieri C, Tumini E, Porcellini E, Caldarera C M, Nanni S, Branzi A, Lio D, Caruso M, Hoffmann E, Caruso C, Licastro F
Abstract excerpt
Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6...
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