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Article

In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2002

Jenny Nancy S, Tracy Russell P, Ogg Malcolm S, Luong Le Ahn, Kuller Lewis H, Arnold Alice M, Sharrett A Richey, Humphries Steve E

Abstract excerpt

OBJECTIVE: Interleukin (IL)-6-mediated inflammation is involved in cardiovascular disease (CVD). We assessed IL-6 levels and the -174G>C genotype in a case-control study of men and women (average age 73 years) within the Cardiovascular Health Study. METHODS AND RESULTS: Cases included incident angina, myocardial infarction (MI), and stroke (5-year follow-up), prevalent MI, and MRI-detectable infarcts. A control...

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Identifiers

PMID: 12482836
DOI: 10.1161/01.atv.0000040224.49362.60

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease.PMID 12482836Read ↗

The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans.Semantic proximity Read ↗

Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction.Semantic proximity Read ↗

Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.Semantic proximity Read ↗

Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis.Semantic proximity Read ↗

No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors.Semantic proximity Read ↗

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Interleukin 6(-174G/C) variant and its circulating levels in coronary artery disease patients and their first degree relatives.Semantic proximity Read ↗

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