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Article

The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans.

Experimental gerontology - 1 Feb 2004

Bruunsgaard Helle, Christiansen Lene, Pedersen Agnes N, Schroll Marianne, Jørgensen Torben, Pedersen Bente Klarlund

Abstract excerpt

Chronic low-grade elevations in circulating levels of interleukin (IL)-6 act as a marker of subclinical cardiovascular diseases (CVD) and provide an independent predictor of increased mortality in elderly populations. The purpose of the present study was to test the hypothesis that the IL-6 -174G>C promoter polymorphism was associated with a high prevalence of CVD and acted as an independent predictor of...

Topics

Aged
Aged, 80 and over
Biomarkers
Cardiovascular Diseases
Denmark
Female
Genetic Predisposition to Disease
Humans
Interleukin-6
Longitudinal Studies
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mortality

Polymorphism, Genetic

Proportional Hazards Models

Smoking

Survival Analysis

Source

Identifiers

PMID: 15036420
DOI: 10.1016/j.exger.2003.10.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans.PMID 15036420Read ↗

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