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Article

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.

Journal of virology - 1 Sept 2004

Rücker Elke, Münch Jan, Wildum Steffen, Brenner Matthias, Eisemann Jutta, Margolis Leonid, Kirchhoff Frank

Abstract excerpt

We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-rich region does not significantly affect the functional activity of Nef or HIV-1 infectivity or replication.

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Identifiers

PMID: 15331753
DOI: 10.1128/JVI.78.18.10197-10201.2004
PMCID: PMC514962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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