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Article

Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.

Journal of virology - 1 Oct 2008

Baugh Laura L, Garcia J Victor, Foster John L

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef downregulates major histocompatibility complex class I (MHC-I) from the cell surface. It has been proposed that the direct interaction of the acidic cluster (AC) of Nef, (62)EEEE(65), with the furin binding region (fbr) of PACS-1 is crucial for this Nef function. Contrary to this proposal, evidence is presented here that the four glutamates in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18653452
DOI: 10.1128/JVI.00107-08
PMCID: PMC2546962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.PMID 18653452Read ↗

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