Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity.

Journal of virology - 1 Jul 2001

Fackler O T, d'Aloja P, Baur A S, Federico M, Peterlin B M

Abstract excerpt

Human immunodeficiency virus type 1(F12) (HIV-1(F12)) interferes with the replication of other strains of HIV. Its accessory protein, Nef, is sufficient for this phenotype, where the production and infectivity of HIV are impaired significantly. The analysis of three rare mutations in this Nef protein revealed that these effects could be separated genetically. Moreover, the defect in virus production correlated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8 Antigens
Share to Down-Regulation
Share to Gene Products, gag

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, nef

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Protein Precursors

Share to Virulence

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 11413327
DOI: 10.1128/JVI.75.14.6601-6608.2001
PMCID: PMC114383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity.PMID 11413327Read ↗

HIV ‐1 Nef: Taking Control of Protein TraffickingSemantic proximity Read ↗

Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.Semantic proximity Read ↗

Cell-dependent functional roles of HIV-1 Nef for virus replication (review).Semantic proximity Read ↗

Functional characterization of HIV-1 Nef mutants in the context of viral infection.Semantic proximity Read ↗

Comparative Proteomic Analysis of HIV-1 Particles Reveals a Role for Ezrin and EHD4 in the Nef-Dependent Increase of Virus InfectivitySemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking PathwaysSemantic proximity Read ↗

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read ↗

Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997).Semantic proximity Read ↗

The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.Semantic proximity Read ↗

Association of Nef with the Human Immunodeficiency Virus Type 1 CoreSemantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 NefSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.