Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS.

doi:10.1128/JVI.75.8.3657-3665.2001

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Article

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS.

Journal of virology - 1 Apr 2001

Carl S, Greenough T C, Krumbiegel M, Greenberg M, Skowronski J, Sullivan J L, Kirchhoff F

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Nef protein has several independent functions that might contribute to efficient viral replication in vivo. Since HIV-1 adapts rapidly to its host environment, we investigated if different Nef properties are associated with disease progression. Functional analysis revealed that nef alleles obtained during late stages of infection did not efficiently downmodulate...

Topics

Acquired Immunodeficiency Syndrome
Alleles
CD4 Antigens
Cell Line
Cohort Studies
Consensus Sequence
Disease Progression
Down-Regulation
Gene Products, nef
HIV-1
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Jurkat Cells

Models, Biological

Time Factors

Virus Latency

Virus Replication

nef Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 11264355
DOI: 10.1128/JVI.75.8.3657-3665.2001
PMCID: PMC114857

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