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Article

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS.

Journal of virology - 1 Apr 2001

Carl S, Greenough T C, Krumbiegel M, Greenberg M, Skowronski J, Sullivan J L, Kirchhoff F

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Nef protein has several independent functions that might contribute to efficient viral replication in vivo. Since HIV-1 adapts rapidly to its host environment, we investigated if different Nef properties are associated with disease progression. Functional analysis revealed that nef alleles obtained during late stages of infection did not efficiently downmodulate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Products, nef

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Source

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Identifiers

PMID: 11264355
DOI: 10.1128/JVI.75.8.3657-3665.2001
PMCID: PMC114857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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