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Article

Regions of Human Immunodeficiency Virus Type 1 nef Required for Function In Vivo

1 Sept 1998

Abstract excerpt

In vivo studies in monkeys and humans have indicated that immunodeficiency viruses with Nef deleted are nonpathogenic in immunocompetent hosts, and this has motivated a search for live attenuated vaccine candidates. However, the mechanisms of action of Nef remain elusive. To define the regions of human immunodeficiency virus type 1 (HIV-1) Nef which mediate in vivo pathogenicity, a series of mutated isogenic...

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PMID: 9696795
DOI: 10.1128/jvi.72.9.7032-7039.1998

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