Article
Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.
Journal of virology - 1 Jul 1999
Kirchhoff F, Easterbrook P J, Douglas N, Troop M, Greenough T C, Weber J, Carl S, Sullivan J L, Daniels R S
Abstract excerpt
nef alleles derived from a large number of individuals infected with human immunodeficiency virus type 1 (HIV-1) were analyzed to investigate the frequency of disrupted nef genes and to elucidate whether specific amino acid substitutions in Nef are associated with different stages of disease. We confirm that deletions or gross abnormalities in nef are rarely present. However, a comparison of Nef consensus...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- CD4 Lymphocyte Count
- Cohort Studies
- DNA, Viral
- Disease Progression
- Gene Products, nef
- Genes, Viral
- Genetic Variation
- HIV Infections
- HIV-1
- Humans