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Article

Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.

Journal of virology - 1 Jul 1999

Kirchhoff F, Easterbrook P J, Douglas N, Troop M, Greenough T C, Weber J, Carl S, Sullivan J L, Daniels R S

Abstract excerpt

nef alleles derived from a large number of individuals infected with human immunodeficiency virus type 1 (HIV-1) were analyzed to investigate the frequency of disrupted nef genes and to elucidate whether specific amino acid substitutions in Nef are associated with different stages of disease. We confirm that deletions or gross abnormalities in nef are rarely present. However, a comparison of Nef consensus...

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Source

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Identifiers

PMID: 10364298
DOI: 10.1128/JVI.73.7.5497-5508.1999
PMCID: PMC112607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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