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Article

Human Immunodeficiency Virus <i>nef</i> Signature Sequences Are Associated with Pulmonary Hypertension

9 Nov 2011

Abstract excerpt

Severe pulmonary hypertension (PH) associated with vascular remodeling is a long-term complication of HIV infection (HIV-PH) affecting 1/200 infected individuals vs. 1/200,000 frequency in the uninfected population. Factors accounting for increased PH susceptibility in HIV-infected individuals are unknown. Rhesus macaques infected with chimeric SHIVnef virions but not with SIV display PH-like pulmonary vascular...

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PMID: 22066947
DOI: 10.1089/aid.2011.0021

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