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Article

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.

Retrovirology - 27 Apr 2012

Meuwissen Pieter J, Stolp Bettina, Iannucci Veronica, Vermeire Jolien, Naessens Evelien, Saksela Kalle, Geyer Matthias, Vanham Guido, Arien Kevin K, Fackler Oliver T, Verhasselt Bruno

Abstract excerpt

BACKGROUND: The Nef protein of HIV facilitates virus replication and disease progression in infected patients. This role as pathogenesis factor depends on several genetically separable Nef functions that are mediated by interactions of highly conserved protein-protein interaction motifs with different host cell proteins. By studying the functionality of a series of nef alleles from clinical isolates, we...

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Topics

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Share to Actin Cytoskeleton
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Jurkat Cells

Share to nef Gene Products, Human Immunodeficiency Virus

Share to p21-Activated Kinases

Share to Phenylalanine

Share to Receptors, CXCR4

Share to trans-Golgi Network

Source

Open in PubMed Open full text

Identifiers

PMID: 22537596
DOI: 10.1186/1742-4690-9-34
PMCID: PMC3476393

Genes

VGF
CXCR4
PAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.PMID 22537596Read ↗

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