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Article

Functional characterization of HIV-1 Nef mutants in the context of viral infection.

Virology - 1 Aug 2006

Fackler Oliver T, Moris Arnaud, Tibroni Nadine, Giese Simone I, Glass Bärbel, Schwartz Olivier, Kräusslich Hans-Georg

Abstract excerpt

Nef is an important pathogenesis factor of HIV-1 with a multitude of effector functions. We have designed a broad panel of isogenic viruses encoding defined mutants of HIV-1(SF2) Nef and analyzed their biological activity in the context of productive HIV-1 infection. Analysis of subcellular localization, virion incorporation, downregulation of cell surface CD4 and MHC-I, enhancement of virion infectivity and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to nef Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 16684552
DOI: 10.1016/j.virol.2006.03.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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