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Article

Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.

Journal of virology - 1 Feb 2003

Stoddart Cheryl A, Geleziunas Romas, Ferrell Sharon, Linquist-Stepps Valerie, Moreno Mary E, Bare Christopher, Xu Weiduan, Yonemoto Wes, Bresnahan Patricia A, McCune Joseph M, Greene Warner C

Abstract excerpt

The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus type 1 (SIV-1) increase viral loads in infected hosts and accelerate clinical progression to AIDS. Nef exhibits a spectrum of biological activities, including the ability to downregulate surface expression of CD4 and major histocompatibility complex (MHC) class I antigens, to alter the state of T-cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12525647
DOI: 10.1128/jvi.77.3.2124-2133.2003
PMCID: PMC140869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.PMID 12525647Read ↗

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 NefSemantic proximity Read ↗

CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 + T-Cell Depletion in Human Lymphoid Tissue Ex VivoSemantic proximity Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID miceSemantic proximity Read ↗

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.Semantic proximity Read ↗

Regions of Human Immunodeficiency Virus Type 1 nef Required for Function In VivoSemantic proximity Read ↗

The Nef protein of primate lentivirusesSemantic proximity Read ↗

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.Semantic proximity Read ↗

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytesSemantic proximity Read ↗

Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.Semantic proximity Read ↗

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.Semantic proximity Read ↗

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