Article
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
Nature - 17 Jan 2002
Barouch Dan H, Kunstman Jennifer, Kuroda Marcelo J, Schmitz Jörn E, Santra Sampa, Peyerl Fred W, Krivulka Georgia R, Beaudry Kristin, Lifton Michelle A, Gorgone Darci A, Montefiori David C, Lewis Mark G, Wolinsky Steven M, Letvin Norman L
Abstract excerpt
Potent virus-specific cytotoxic T lymphocyte (CTL) responses elicited by candidate AIDS vaccines have recently been shown to control viral replication and prevent clinical disease progression after pathogenic viral challenges in rhesus monkeys. Here we show that viral escape from CTL recognition can result in the eventual failure of this partial immune protection. Viral mutations that escape from CTL recognition...
Topics
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Amino Acid Substitution
- Animals
- CD8-Positive T-Lymphocytes
- DNA Mutational Analysis
- Epitopes, T-Lymphocyte
- Genes, gag
- HIV-1