Article
Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection.
European journal of immunology - 1 Nov 2001
Kaur A, Alexander L, Staprans S I, Denekamp L, Hale C L, McClure H M, Feinberg M B, Desrosiers R C, Johnson R P
Abstract excerpt
Although CTL escape has been well documented in pathogenic simian immunodeficiency virus (SIV) infection, there is no information on CTL escape in nonpathogenic SIV infection in nonhuman primate hosts like the sooty mangabeys. CTL responses and sequence variation in the SIV nef gene were evaluated in one sooty mangabey and one rhesus macaque inoculated together with the same stock of cloned SIVmac239. Each animal...
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