Article
Vaccination with CTL epitopes that escape: an alternative approach to HIV vaccine development?
Immunology letters - 1 Nov 2001
O'Connor D, Allen T, Watkins D I
Abstract excerpt
This article describes a novel approach to HIV vaccine design that is, as yet, unproven and still in preliminary development. In rhesus macaques infected with simian immunodeficiency virus (SIV), we have identified particular cellular immune responses that select for viral variants during primary infection. We speculate that the detection of viral variants with altered amino acids in CTL epitopes implies the...
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