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Article

Comparison of three methods for estimating rates of synonymous and nonsynonymous nucleotide substitutions.

Molecular biology and evolution - 1 Dec 2004

Tzeng Yun-Huei, Pan Runsun, Li Wen-Hsiung

Abstract excerpt

Three frequently used methods for estimating the synonymous and nonsynonymous substitution rates (Ks and Ka) were evaluated and compared for their accuracies; these methods are denoted by LWL85, LPB93, and GY94, respectively. For this purpose, we used a codon-evolution model to obtain the expected Ka and Ks values for the above three methods and compared the values with those obtained by the three methods. We...

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PMID: 15329386
DOI: 10.1093/molbev/msh242

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