Article
A simple method for estimating the parameter of substitution rate variation among sites.
Molecular biology and evolution - 1 Nov 1997
Gu X, Zhang J
Abstract excerpt
When the rate variation among sites is described by a gamma distribution, an important problem is how to estimate the shape parameter alpha, which is an index of the degree of among-site rate variation. The parsimony-based methods for estimating alpha are simple but biased, i.e., alpha tends to b...
Topics
- Amino Acid Sequence
- Computer Simulation
- Evolution, Molecular
- Genetic Variation
- Likelihood Functions
- Models, Genetic
- Proteins