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Article

Towards realistic codon models: among site variability and dependency of synonymous and non-synonymous rates.

Bioinformatics (Oxford, England) - 1 Jul 2007

Mayrose Itay, Doron-Faigenboim Adi, Bacharach Eran, Pupko Tal

Abstract excerpt

Codon evolutionary models are widely used to infer the selection forces acting on a protein. The non-synonymous to synonymous rate ratio (denoted by Ka/Ks) is used to infer specific positions that are under purifying or positive selection. Current evolutionary models usually assume that only the non-synonymous rates vary among sites while the synonymous substitution rates are constant. This assumption ignores the...

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PMID: 17646313
DOI: 10.1093/bioinformatics/btm176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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