Variation in the pattern of nucleotide substitution across sites.

doi:10.1007/pl00006448

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Article

Variation in the pattern of nucleotide substitution across sites.

Journal of molecular evolution - 1 Jan 1999

Huelsenbeck J P, Nielsen R

Abstract excerpt

A model of nucleotide substitution that allows the transition/transversion rate bias to vary across sites was constructed. We examined the fit of this model using likelihood-ratio tests by analyzing 13 protein coding genes and 1 pseudogene. Likelihood-ratio testing indicated that a model that all...

Topics

Animals
Codon
DNA, Mitochondrial
Evolution, Molecular
Genes
Genetic Variation
Humans
Likelihood Functions
Models, Genetic
Phylogeny
Point Mutation
Pseudogenes

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