Correlations of nucleotide substitution rates and base composition of mammalian coding sequences with protein structure.

doi:10.1016/s0378-1119(99)00258-9

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Article

Correlations of nucleotide substitution rates and base composition of mammalian coding sequences with protein structure.

Gene - 30 Sept 1999

Chiusano M L, D'Onofrio G, Alvarez-Valin F, Jabbari K, Colonna G, Bernardi G

Abstract excerpt

We investigated the relationships between the nucleotide substitution rates and the predicted secondary structures in the three states representation (alpha-helix, beta-sheet, and coil). The analysis was carried out on 34 alignments, each of which comprised sequences belonging to at least four different mammalian orders. The rates of synonymous substitution were found to be significantly different in regions...

Topics

Animals
Base Composition
Codon
Mammals
Mutation
Protein Structure, Secondary

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Open in PubMed

Identifiers

PMID: 10570980
DOI: 10.1016/s0378-1119(99)00258-9

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