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Article

Substitution-Mutation Rate Ratio (c/µ) As Molecular Adaptation Test Beyond Ka/Ks: A SARS-COV-2 Case Study.

Journal of molecular evolution - 1 Jun 2025

Wu Chun, Paradis Nicholas J, Jain Khushi

Abstract excerpt

The Ka/Ks ratio test, which assesses nonsynonymous versus synonymous substitution rates in Translated Region (TR) of a genome, is widely used to quantify fitness changes due to mutations but its critical limits are to be addressed. Ka/Ks can categorize the total fitness change as neutral (Ka/Ks = 1), beneficial (Ka/Ks > 1), or deleterious (Ka/Ks < 1), only if synonymous mutations are neutral. Otherwise, Ka/Ks...

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Share to Amino Acid Substitution
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Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome, Viral

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Source

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Identifiers

PMID: 40319123
DOI: 10.1007/s00239-025-10248-6
PMCID: PMC12198311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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