Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells.

The Journal of biological chemistry - 22 Oct 2004

Vallés Ana M, Beuvin Maud, Boyer Brigitte

Abstract excerpt

Induction of epithelial cell motility is a fundamental morphogenetic event that is recapitulated during carcinoma metastasis. Random motility of NBT-II carcinoma cells on collagen critically depends on paxillin phosphorylation at Tyr-31 and Tyr-118, the binding sites for the adapter protein CrkII. Two constitutive partners of CrkII are the exchange factors DOCK180 and C3G. CrkII bound to DOCK180 formed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen
Share to GTP Phosphohydrolases
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paxillin

Share to Phosphoproteins

Share to rac GTP-Binding Proteins

Share to rac1 GTP-Binding Protein

Share to Tyrosine

Source

Identifiers

PMID: 15308668
DOI: 10.1074/jbc.M405144200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells.PMID 15308668Read ↗

Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration.Semantic proximity Read ↗

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.Semantic proximity Read ↗

Regulation of cancer cell motility through actin reorganizationSemantic proximity Read ↗

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.Semantic proximity Read ↗

Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.Semantic proximity Read ↗

Stress-activated MAPKs and CRM1 regulate the subcellular localization of Net1A to control cell motility and invasion.Semantic proximity Read ↗

EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.Semantic proximity Read ↗

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.Semantic proximity Read ↗

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.Semantic proximity Read ↗

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.Semantic proximity Read ↗

The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.Semantic proximity Read ↗

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.