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Article

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.

The Journal of cell biology - 30 Nov 1998

Sander E E, van Delft S, ten Klooster J P, Reid T, van der Kammen R A, Michiels F, Collard J G

Abstract excerpt

We previously demonstrated that both Tiam1, an activator of Rac, and constitutively active V12Rac promote E-cadherin-mediated cell-cell adhesion in epithelial Madin Darby canine kidney (MDCK) cells. Moreover, Tiam1 and V12Rac inhibit invasion of Ras-transformed, fibroblastoid MDCK-f3 cells by restoring E-cadherin-mediated cell-cell adhesion. Here we show that the Tiam1/Rac-induced cellular response is dependent...

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Identifiers

PMID: 9832565
DOI: 10.1083/jcb.143.5.1385
PMCID: PMC2133078

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.PMID 9832565Read ↗

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.Semantic proximity Read ↗

The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions.Semantic proximity Read ↗

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration.Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signalingSemantic proximity Read ↗

Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.Semantic proximity Read ↗

Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion.Semantic proximity Read ↗

Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.Semantic proximity Read ↗

Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells.Semantic proximity Read ↗

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.Semantic proximity Read ↗

VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.Semantic proximity Read ↗

SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.Semantic proximity Read ↗

Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain.Semantic proximity Read ↗

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