Article
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.
The Journal of cell biology - 30 Nov 1998
Sander E E, van Delft S, ten Klooster J P, Reid T, van der Kammen R A, Michiels F, Collard J G
Abstract excerpt
We previously demonstrated that both Tiam1, an activator of Rac, and constitutively active V12Rac promote E-cadherin-mediated cell-cell adhesion in epithelial Madin Darby canine kidney (MDCK) cells. Moreover, Tiam1 and V12Rac inhibit invasion of Ras-transformed, fibroblastoid MDCK-f3 cells by res...
Topics
- Animals
- Base Sequence
- Cadherins
- Cell Adhesion
- Cell Line
- Cell Movement
- Collagen
- DNA Primers
- Dogs
- Epithelial Cells
- Extracellular Matrix
- Fibronectins
- GTP-Binding Proteins
- Phenotype
- Phosphatidylinositol 3-Kinases