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Article

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.

Molecular biology of the cell - 1 Dec 2012

Saito Koji, Ozawa Yuta, Hibino Keisuke, Ohta Yasutaka

Abstract excerpt

Tumor cells exhibit two interconvertible modes of cell motility referred to as mesenchymal and amoeboid migration. Mesenchymal mode is characterized by elongated morphology that requires high GTPase Rac activation, whereas amoeboid mode is dependent on actomyosin contractility induced by Rho/Rho-associated protein kinase (ROCK) signaling. While elongated morphology is driven by Rac-induced protrusion at the...

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Identifiers

PMID: 23097497
DOI: 10.1091/mbc.E12-04-0310
PMCID: PMC3521682

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