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Article

Stress-activated MAPKs and CRM1 regulate the subcellular localization of Net1A to control cell motility and invasion.

Journal of cell science - 1 Feb 2018

Ulu Arzu, Oh Wonkyung, Zuo Yan, Frost Jeffrey A

Abstract excerpt

The neuroepithelial cell transforming gene 1A (Net1A, an isoform of Net1) is a RhoA subfamily guanine nucleotide exchange factor (GEF) that localizes to the nucleus in the absence of stimulation, preventing it from activating RhoA. Once relocalized in the cytosol, Net1A stimulates cell motility and extracellular matrix invasion. In the present work, we investigated mechanisms responsible for the cytosolic...

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Identifiers

PMID: 29361525
DOI: 10.1242/jcs.204644
PMCID: PMC5826041

Genes

EGF
MAPK8
MYL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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