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Article

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.

The Journal of biological chemistry - 13 Feb 2004

Grimsley Cynthia M, Kinchen Jason M, Tosello-Trampont Annie-Carole, Brugnera Enrico, Haney Lisa B, Lu Mingjian, Chen Qi, Klingele Doris, Hengartner Michael O, Ravichandran Kodi S

Abstract excerpt

Cell migration is essential throughout embryonic and adult life. In numerous cell systems, the small GTPase Rac is required for lamellipodia formation at the leading edge and movement ability. However, the molecular mechanisms leading to Rac activation during migration are still unclear. Recently, a mammalian superfamily of proteins related to the prototype member Dock180 has been identified with homologues in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14638695
DOI: 10.1074/jbc.M307087200

Genes

ELMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.PMID 14638695Read ↗

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.Semantic proximity Read ↗

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.Semantic proximity Read ↗

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.Semantic proximity Read ↗

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that target different GTPasesSemantic proximity Read ↗

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.Semantic proximity Read ↗

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.Semantic proximity Read ↗

Mutations in the Drosophila tricellular junction protein M6 synergize with RasV12 to induce apical cell delamination and invasion.Semantic proximity Read ↗

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Semantic proximity Read ↗

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.Semantic proximity Read ↗

Biallelic ELMO3 mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability.Semantic proximity Read ↗

LINKIN, a new transmembrane protein necessary for cell adhesion.Semantic proximity Read ↗

LINKIN-associated proteins necessary for tissue integrity during collective cell migrationSemantic proximity Read ↗

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