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Article

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.

Cellular signalling - 1 May 2014

Kobayashi Masakazu, Harada Kohei, Negishi Manabu, Katoh Hironori

Abstract excerpt

Dock4 is a member of the Dock180 family of proteins that mediates cancer cell migration through activation of Rac. However, the regulatory mechanism of Dock4 remains unclear. In this study, we show that the C-terminal proline-rich region of Dock4 is essential for the Dock4 mediated promotion of cell migration in MDA-MB-231 breast cancer cells. We found that a phosphoinositide-binding protein SH3YL1 interacted...

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Source

Identifiers

PMID: 24508479
DOI: 10.1016/j.cellsig.2014.01.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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