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Article

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.

The Journal of cell biology - 25 Nov 2002

Tsubouchi Asako, Sakakura Junko, Yagi Ryohei, Mazaki Yuichi, Schaefer Erik, Yano Hajime, Sabe Hisataka

Abstract excerpt

RhoA activity is transiently inhibited at the initial phase of integrin engagement, when Cdc42- and/or Rac1-mediated membrane spreading and ruffling predominantly occur. Paxillin, an integrin-assembly protein, has four major tyrosine phosphorylation sites, and the phosphorylation of Tyr31 and Tyr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12446743
DOI: 10.1083/jcb.200202117
PMCID: PMC2173105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12446743-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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