Article
Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry - 29 Oct 2004
Wagner Larry E, Li Wen-Hong, Joseph Suresh K, Yule David I
Abstract excerpt
Regulation of Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) has important consequences for defining the particular spatio-temporal properties of intracellular Ca(2+) signals. In this study, regulation of Ca(2+) release by phosphorylation of type 1 InsP(3)R (InsP(3)R-1) was investigated by constructing "phosphomimetic" charge mutations in the functionally important phosphorylation sites...
Topics
- Animals
- Calcium
- Calcium Channels
- Calcium Signaling
- Cyclic AMP-Dependent Protein Kinases
- Cyclic GMP-Dependent Protein Kinases
- Humans
- Inositol 1,4,5-Trisphosphate Receptors
- Mutation
- Phosphorylation