Article
Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channels.
The Journal of biological chemistry - 27 Apr 2001
Boehning D, Mak D O, Foskett J K, Joseph S K
Abstract excerpt
We tested the hypothesis that key residues in a putative intraluminal loop contribute to determination of ion permeation through the intracellular Ca(2+) release channel (inositol 1,4,5-trisphosphate receptors (IP(3)Rs)) that is gated by the second messenger inositol 1,4,5-trisphosphate (IP(3))....
Topics
- Amino Acid Sequence
- Animals
- Aspartic Acid
- Binding Sites
- COS Cells
- Calcium
- Calcium Channels
- Cations
- Cell Membrane
- Electrophysiology
- Inositol 1,4,5-Trisphosphate
- Ions
- Models, Biological
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Neurons
- Patch-Clamp Techniques