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Article

Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.

Biophysical journal - 1 Jun 2004

Srikanth Sonal, Wang Zhengnan, Tu Huiping, Nair Shalima, Mathew M K, Hasan Gaiti, Bezprozvanny Ilya

Abstract excerpt

The inositol (1,4,5)-trisphosphate receptor (InsP(3)R) is an intracellular calcium (Ca(2+)) release channel that plays a crucial role in cell signaling. In Drosophila melanogaster a single InsP(3)R gene (itpr) encodes a protein (DmInsP(3)R) that is approximately 60% conserved with mammalian InsP(3)Rs. A number of itpr mutant alleles have been identified in genetic screens and studied for their effect on...

Topics

Animals
Calcium
Calcium Channels
Cells, Cultured
Drosophila melanogaster
Inositol
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Lipid Bilayers
Mutation
Receptors, Cytoplasmic and Nuclear

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Identifiers

PMID: 15189860
DOI: 10.1529/biophysj.104.040121
PMCID: PMC1304265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15189860-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.PMID 15189860Read ↗

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