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Article

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

The Journal of biological chemistry - 12 Nov 2010

Yamazaki Haruka, Chan Jenny, Ikura Mitsuhiko, Michikawa Takayuki, Mikoshiba Katsuhiko

Abstract excerpt

The N-terminal ∼220-amino acid region of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)/Ca(2+) release channel has been referred to as the suppressor/coupling domain because it is required for both IP(3) binding suppression and IP(3)-induced channel gating. Measurements of IP(3)-induced Ca(2+) fluxes of mutagenized mouse type 1 IP(3)R (IP(3)R1) showed that the residues responsible for IP(3) binding...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Binding Sites
Blotting, Western
Calcium
Cell Line, Tumor
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ligands

Mice

Models, Molecular

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Protein Binding

Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 20813840
DOI: 10.1074/jbc.M110.140129
PMCID: PMC2975230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20813840-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.PMID 20813840Read ↗

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