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Article

Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.

PloS one - 1 Jan 2014

Liu Bin, Lopez Joseph J, Biesiadecki Brandon J, Davis Jonathan P

Abstract excerpt

Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect of β-adrenergic related PKA phosphorylation of troponin I at Ser23/24 is well established, the effects of α-adrenergic induced PKC phosphorylation on multiple...

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Identifiers

PMID: 24466001
DOI: 10.1371/journal.pone.0086279
PMCID: PMC3899258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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