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Article

ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action.

The Journal of biological chemistry - 1 Aug 2008

Betzenhauser Matthew J, Wagner Larry E, Iwai Miwako, Michikawa Takayuki, Mikoshiba Katsuhiko, Yule David I

Abstract excerpt

ATP enhances Ca(2+) release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R). However, the three isoforms of InsP(3)R are reported to respond to ATP with differing sensitivities. Ca(2+) release through InsP(3)R1 is positively regulated at lower ATP concentrations than InsP(3)R3, and InsP(3)R2 has been reported to be insensitive to ATP modulation. We have reexamined these differences by studying the...

Topics

Adenosine Triphosphate
Animals
Binding Sites
Calcium
Calcium Signaling
Cell Line
Chickens
DNA Mutational Analysis
Glutathione Transferase
Inositol 1,4,5-Trisphosphate Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Probability

Signal Transduction

Transfection

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Identifiers

PMID: 18505727
DOI: 10.1074/jbc.M801680200
PMCID: PMC2490775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18505727-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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