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Article

Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation.

The Journal of biological chemistry - 22 Oct 2004

Kanei-Ishii Chie, Nomura Teruaki, Tanikawa Jun, Ichikawa-Iwata Emi, Ishii Shunsuke

Abstract excerpt

Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein kinase 2), and NLK (Nemo-like kinase). NLK and HIPK2 bind directly to c-Myb, which results in the phosphorylation of c-Myb at multiple sites, followed by its ubiquitination and...

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Source

Identifiers

PMID: 15308626
DOI: 10.1074/jbc.M407831200

Genes

HIPK2
NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation.PMID 15308626Read ↗

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