Article
Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.
Oncogene - 10 Jun 1999
Dubendorff J W, Lipsick J S
Abstract excerpt
The c-Myb protein binds to DNA, can regulate transcription, and is required for normal hematopoiesis in vertebrates. Either amino- or carboxy-terminal truncation of this protein is required for efficient oncogenic activation. Previous studies have shown that the carboxyl terminus of c-Myb that is deleted in v-Myb contains negative regulatory domains. We now demonstrate that specific mutations within this carboxyl...
Topics
- Animals
- Binding Sites
- Cell Line
- DNA
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- Oncogene Proteins v-myb
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myb
- Quail
- Retroviridae Proteins, Oncogenic
- Sequence Alignment
- Sequence Deletion
- Trans-Activators
- Transcriptional Activation