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Article

Requirement of c-myb in T cell development and in mature T cell function.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 2004

Lieu Yen K, Kumar Atul, Pajerowski Anthony G, Rogers Thomas J, Reddy E Premkumar

Abstract excerpt

Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development of thymocytes at the DN3 stage, for survival and proliferation of double-positive thymocytes, for differentiation...

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Identifiers

PMID: 15466706
DOI: 10.1073/pnas.0405338101
PMCID: PMC522009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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