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Article

Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.

Molecular and cellular biology - 1 Nov 2001

Nicot C, Mahieux R, Pise-Masison C, Brady J, Gessain A, Yamaoka S, Franchini G

Abstract excerpt

The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb transcription can transform cells of lymphoid origin by stimulating cellular proliferation and inhibiting apoptotic pathways. Here we demonstrate that activation of the NF-kappaB pathway by the HTLV-1 Tax protein leads to...

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Identifiers

PMID: 11585920
DOI: 10.1128/MCB.21.21.7391-7402.2001
PMCID: PMC99912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.PMID 11585920Read ↗

HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300.Semantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.Semantic proximity Read ↗

Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.Semantic proximity Read ↗

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.Semantic proximity Read ↗

Transactivation of the murine c-myc gene by HTLV-1 tax is mediated by NFkB.Semantic proximity Read ↗

Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation.Semantic proximity Read ↗

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.Semantic proximity Read ↗

Myb-induced transformation.Semantic proximity Read ↗

Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Semantic proximity Read ↗

IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.Semantic proximity Read ↗

Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300.Semantic proximity Read ↗

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