Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.

doi:10.1128/MCB.21.21.7391-7402.2001

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Article

Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.

Molecular and cellular biology - 1 Nov 2001

Nicot C, Mahieux R, Pise-Masison C, Brady J, Gessain A, Yamaoka S, Franchini G

Abstract excerpt

The proto-oncogene c-myb is essential for a controlled balance between cell growth and differentiation. Aberrant c-Myb activity has been reported for numerous human cancers, and enforced c-Myb transcription can transform cells of lymphoid origin by stimulating cellular proliferation and inhibiting apoptotic pathways. Here we demonstrate that activation of the NF-kappaB pathway by the HTLV-1 Tax protein leads to...

Topics

Animals
Cell Differentiation
Cell Division
Cell Line
DNA-Binding Proteins
E1A-Associated p300 Protein
Enzyme Activation
Gene Deletion
Gene Products, tax
I-kappa B Proteins

Immunoblotting

Interleukin-1

Ligases

Luciferases

Mice

Mice, Knockout

Microscopy, Fluorescence

Mutation

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